Life Extension Update Exclusive
Experimental research finds silibinin reduces the growth of liver cancer
A report published in the October 28, 2007 issue of the World Journal
of Gastroenterology described the finding of hepatologist Ke-Qin Hu,
John J Lah and Wei Cui at the University of California, Irvine that
silibinin, derived from milk thistle, significantly reduces the growth
of several human liver cancer cell lines. The compound has previously
demonstrated an inhibitory effect on prostate, colon, skin, bladder and
lung cancer cell cultures.
Silibinin is a polyphenolic flavonoid and the major biologically active
compound of the milk thistle plant. Milk thistle has long been used as
an herbal remedy for liver disease and has been shown to have a
protective effect on the organ against alcohol or drug related damage.
In the current study, Dr Hu's team treated four different human
hepatocellular carcinoma (HCC) cell lines with varying doses of
silibinin, and examined the compound’s effect on cell growth and
proliferation, apoptosis, cell cycle progression, histone acetylation,
and other related processes.
The team found a dose-dependent inhibition of tumor growth associated
with silibinin compared to untreated cells in all lines tested. They
discovered that silibinin decreased cancer cell proliferation and cell
cycle progression, enhanced apoptosis (programmed cell
self-destruction), and altered the genetic structure of the cancerous
cells. At a higher concentration, silibinin also showed an inhibitory
effect on two markers of angiogenesis.
"Our results defined silibinin's in vitro anti-HCC effects and possible
mechanisms, and provided a rationale to further test silibinin for HCC
chemoprevention," the authors conclude.
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Silibinin Plus
Silibinin is of particular importance for those who may have concerns
for the health of their liver. The most biologically active
flavonolignan found in silymarin is silibinin. Standardized milk thistle
extract usually consists of 60-70% silibinin. Silibinin’s main
hepatoprotective properties are that of free radical scavenger and
membrane stabilizer. Other important antioxidant effects of silibinin
are due to its influence on the superoxide dismutase and the enzyme
system associated with glutathione. In addition, silymarin and silibinin
actually help maintain a normal rate of protein synthesis in the liver,
leading to more efficient cellular functions such as cell division.
Silibinin’s influence on the 5-lipooxygenase pathway can also
account for its role in supporting healthy liver function.
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Mega Silymarin with Isosilybin B
The botanical extract in Mega Silymarin is a triple standardized milk
thistle extract. In addition to an optimal 80% standardization of the
main active compounds, silymarin flavonolignans, Mega Silymarin is
further standardized to two highly active isomers - silibinin and
isosilybin B. Most premium milk thistle extracts are void of or lack
consistent amounts of the most active flavonolignan isomer isosilybin B.
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